A topical cream containing glucosamine and chondroitin sulphate – osteoarthritis of the knee

A topical cream containing glucosamine and chondroitin sulphate – osteoarthritis of the knee

Cohen, M. Wolfe, R. Mai, T. Lewis, D. A topical cream containing glucosamine and chondroitin sulphate reduced joint pain in osteoarthritis of the knee Evid. Based Med. 2003;8;154

Abstract

 

OBJECTIVE:

To assess the ability of a topical preparation of glucosamine sulfate and chondroitin sulfate to reduce pain related to osteoarthritis (OA) of the knee.

METHODS:

Sixty-three patients were randomized to receive either a topical glucosamine and chondroitin preparation or placebo to be used as required over an 8 week period. Efficacy was assessed using a visual analog scale (VAS) for pain as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the SF-36 questionnaire.

RESULTS:

VAS scores indicated a greater mean reduction in pain for the glucosamine/chondroitin preparation group (mean change -3.4 cm, SD 2.6 cm) compared to the placebo group (mean change -1.6 cm, SD 2.7 cm) after 8 weeks. After 4 weeks the difference between active and placebo groups in their mean reduction from baseline was 1.2 (95% CI 0.1 to 2.4, p = 0.03) and after 8 weeks was 1.8 (95% CI for difference between groups, 0.6 to 2.9 cm; p = 0.002).

CONCLUSION:

Topical application of glucosamine and chondroitin sulfate is effective in relieving the pain from OA of the knee and improvement is evident within 4 weeks.

A randomised, double-blind, placebo-controlled trial – osteoarthritis of the knee

A randomised, double-blind, placebo-controlled trial – osteoarthritis of the knee

Cohen, M. A Randomised, Double-blind, Placebo-controlled Trial of a Topical Cream containing Glucosamine Sulfate Chondroitin Sulfate and Camphor for Osteoarthritis of the Knee. Journal of Rheumatology, Authors Reply. 31 (4):826-827, 2004

Abstract

 

Objective. To assess the ability of a topical preparation of glucosamine sulfate and chondroitin sulfate to reduce pain related to osteoarthritis (OA) of the knee. Methods. Sixty-three patients were randomized to receive either a topical glucosamine and chondroitin preparation or placebo to be used as required over an 8 week period. Efficacy was assessed using a visual analog scale (VAS) for pain as well as the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and the SF-36 questionnaire. Results. VAS scores indicated a greater mean reduction in pain for the glucosamine/chondroitin preparation group (mean change –3.4 cm, SD 2.6 cm) compared to the placebo group (mean change –1.6 cm, SD 2.7 cm) after 8 weeks. After 4 weeks the difference between active and placebo groups in their mean reduction from baseline was 1.2 (95% CI 0.1 to 2.4, p = 0.03) and after 8 weeks was 1.8 (95% CI for difference between groups, 0.6 to 2.9 cm; p = 0.002). Conclusion. Topical application of glucosamine and chondroitin sulfate is effective in relieving the pain from OA of the knee and improvement is evident within 4 weeks. (J Rheumatol 2003;30:523–8)

Single Cell Food

Single Cell Food

Cohen, M. & Jamieson, J. Single Cell Food. Journal of Complementary Medicine, 2006 5(2): 85-91

Abstract

 

Nutritionists and public-health authorities agree that the Australian population needs to increase its dietary intake of plant-based foods. Many would also encourage the consumption of organically produced ‘whole foods’ involving minimal processing, including those at the base of the food chain so as to reduce bio-accumulation of environmental toxins.